|
KMID : 0644120080210010039
|
|
Journal of Oriental Gynecology
2008 Volume.21 No. 1 p.39 ~ p.54
|
|
|
Anti-inflammatory Effects of Omisodokeum
|
|
Seo Yun-Jung
Cho Han-Baek
Choe Chang-Min
Lee Soon-Yee
Kim Song-Baeg
|
|
|
Abstract
|
|
|
|
Purpose: The purpose of this study was to investigate the anti-inflammatory effects of the water extract of Omisodokeum (OMSDE) on peritoneal macrophages, Methods: To verify the anti-inflammatory mechanism of OMSDE, the activation of nuclear and the phosphorylation of MAPK were examined. Results: The extract of OMSDE suppressed the production of LPS-induced nitric oxide (NO), tumor necrosis factor , interleukin , IL-6 and IL-12 in the macrophages. OMSDE inhibited the degradation of inhibitory and it suppressed the activation of extracellular signal-regulated kinase (ERK 1/2) but didn’t inhibit c-Jun N-terminal kinase (JNK) and p38, indicating that OMSDE may inhibit the pro-inflammatory cytokine production process by inhibiting the activation of and ERK 1/2. Furthermore, OMSDE inhibited the production of interferon but didn’t inhibit of in the LPS-stimulated macrophages through the down-regulation of interferon regulatory factor (IRF)-1 and IRF-7. The Oral administration of OMSDE inhibited LPS-induced endotoxin shock and the production of in serum but didn’t inhibit of and IL-6. Conclusion: These results suggest that OMSDE may be effective in the prevention and treatment of inflammatory diseases
|
|
|
KEYWORD
|
|
|
Herbal medicine, nitric oxide (NO), tumor necrosis factor, interleukin (IL), interferon (IFN)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|